BECK LAB
609 Albany Street, J-607
Boston, Massachusetts 02118-2515
"Torture the data, and it will confess to anything"
Ronald Coase
RESEARCH
Big DATA Biology
The volume of cumulated biological data is growing exponentially. We believe that the systematic profiling, reorganization and re-analyses of such large-scale available data can lead us to the whole new level of biological understanding. The ultimate goal of our research is to understand complex biological systems and human diseases using integrative Big Data analyses and experimental validations.
Gene Regulation at Transcription Level
Gene regulation is multi-layered complex process involving transcriptional and epigenetic regulations as well as chromosomal 3-D architectures. We work to decipher the comprehensive biological mechanisms underlying gene regulation at the transcriptional level and how the dysregulation of such process is associated with human diseases, by using integrative data analyses.
Chromatin Architecture in Aging
3-D chromatin architecture changes dynamically under a variety of conditions including cell fate determination, differentiation and development. Disorganization of chromatin architecture is associated with various human diseases and is also a hallmark of aging. We study how chromatin architecture changes give rise to the degenerative phenotype with age.
PEOPLE
Samuel Beck, Ph.D
Assistant Professor. Boston University School of Medicine
Dermatology/Center for Aging Research
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2022- Assistant Professor, Boston University School of Medicine
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2017-2022 Assistant Professor, MDI Biological Laboratory, ME
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2012-2017 Postdoc, The University of Texas at Austin. Systems Biology
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2011 Postdoc, Yonsei University, Network Biology
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2011 Ph.D., Seoul National University
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2004 B.S., Seoul National University
Email: sambeck [at] bu.edu
Vikas Kumar, Ph.D
Postdoctoral associate
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2023- Postdoc. Boston University School of Medicine
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2022-2023 Principal Research Engineer at Linköping University, Sweden
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2018-2022 Associate Professor at Institute of Vertebrate Paleontology and Palaeanthropology, Beijing China
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2016-2018 Postdoc. Senckenberg, Biodiversity & climate research centre, Frankfurt, Germany
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2016 Ph.D., Goethe University, Frankfurt, Germany
Email: vikku19 [at] bu.edu
Byung-Ju Kim, Ph.D
Postdoctoral Associate
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2024-present: Postdoc. Boston University School of Medicine
2022-2024: Research Professor, Convergence Research Center for Insect Vectors, Incheon University
2019-2022: Research Associate, Human Genome Research Center, Incheon National University
2014-2018: Assist Specialist, UC Berkeley
2018: Ph.D., Integrated Omics for Biomedical Science, Yonsei University
Email: byungju [at] bu.edu
Hyun-Jin Kim, B.Sc
Visiting Graduate Student
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2019-present: Ph.D. program, Chonnam National University
Email: hkim3 [at] bu.edu
Volunteer
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Jaeyoon (Jake) Kim (2024-): Thomas Jefferson High School for Science and Tech in Virginia​​
Open position: Postdoctoral researcher
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Fields of interest
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Aging intervention study in mammalian system.​
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Computational biology/Genomics
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Please send the following materials to sambeck [at] bu.edu.​​
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Cover letter briefly highlighting your experience and interests
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C.V.
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Contact information of three references.
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Open position: Undergraduate researcher
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We are seeking passionate undergraduate students to join our team, dedicated to exploring the biology of aging and gene regulation via a combination of computational and experimental approaches. Participants are expected to dedicate a minimum of 10 hours per week to this research project for at least one year.
Alumni
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Postdoc​​
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Jun-Yeong Lee (2017-2022): Currently an Assistant Professor at KyungPook National University, Daegu, Korea​ ​
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Sooin Choi (2023 - 2024)
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​Visiting Scientist
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​HoonHee Seo (2023-2024): Currently an Assistant Professor at Soonchunhyang University
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Rotation Student​
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Ali Gulhan (2024)
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Anna Goldstein (2024)
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Undergraduate​
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Angelica Aguilar (2020): Currently a graduate student, The University of California, San Francisco
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Elise A. Courtney (2020)​
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Elliot Youth (2019): Currently in the MD/PhD program, The University of Chicago
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Ezekiel Robinson (2019)
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Romario Romain (2018): Currently a Research Assistant, Colorado State University
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Research Assistant​
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Ian Davis (2020-2022): Currently a Research Assistant, MDI Biological Laboratory​
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Jessie Bolduc (2018-2020)
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Volunteer​
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Sedam Park (2023-2024)
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PHOTOS
 Lab lunch. January 2024 |  August 2023 |  Lab Photo: April 2021 |
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 Lab photo: June 2019. |  Lab photo: June 2019. |  Lab photo: August, 2018 |
IN THE MEDIA
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Aberrant Heterochromatin, Gene Expression Inflame Old Cells. Alzforum · December 17, 2021
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Aging in Mice Linked to Misexpression of Class of Genes. The Scientist · December 21, 2021
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Gene expressions related to DNA changes due to aging found to be related to CpG islands. Medical Xpress · December 22, 2021
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MDI Biological Laboratory identifies causes of chronic inflammation. ABC7 Bangor Maine · February 24, 2022
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MDI Biological Laboratory scientist identifies mechanism underlying ‘inflammaging’. Bangor Daily News · February 24, 2022
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Architectural Woes Prompt Age-related Problems Thanks to Genes Lacking CpG Islands. Epigenie · January 20, 2022
CONTACT US
Lab address: J-607, 609 Albany Street, Boston, Massachusetts 02118-2515
Phone: (617) 358-7631
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